MLB Opening Day Picks for All 14 Video games

• All however two MLB groups are in motion on Opening Day 2025 (March 27)
• I’ve set out the percentages for all 14 video games, together with moneyline, runline and run complete
• See my MLB Opening Day picks and predictions for every sport on the docket

The 2025 MLB season technically began final week with the Cubs and Dodgers assembly in a two-game set in Japan. However, for the overwhelming majority of the league, Thursday, March 27, marks Opening Day on the brand new season. Within the desk beneath, I’ve set out the percentages (moneyline, unfold, and complete) for all 14 video games on the MLB slate on Thursday. Beneath the desk, discover my choose for every sport, together with the sportsbook that presently has one of the best out there odds for that choose.

MLB Opening Day Odds 2025

Notice that the percentages within the desk above are from DraftKings on March 26. Within the desk beneath, which units out my favourite picks for every sport, I’ve culled one of the best odds for that choose from considered one of 5 books: DK, FanDuel, Caesars, bet365, and BetMGM.

Signal-up on the prime betting websites earlier than MLB Opening Day.

With each staff sending their de facto ace to the mound on Opening Day, there aren’t any vastly lopsided moneyline odds among the many 14 video games on the slate. Zack Wheeler and the Philadelphia Phillies (-175) are the most important favourite of the day on the highway in opposition to Mackenzie Gore and the Washington Nationals. The Mariners (-170) are the one staff staff shorter than -164.

The run totals vary from a mager 6.5 in Pirates vs Marlins to eight.5 in a trio of video games: Tigers vs Dodgers, Cubs vs Diamondbacks, and Orioles vs Blue Jays.

MLB Opening Day Picks & Predictions

All wagers one unit until expressly said in any other case.

The overwhelming majority of my MLB Opening Day picks are moneyline wagers, with eight of them on a plus-money underdog to win outright. 4 of these are residence underdogs.

I’m additionally concentrating on two first-X unders: below 1.5 within the first three innings between the Pirates and Marlins, and below 2.5 within the first 5 innings between the Braves and Padres. Each are electrical pitching matchups. Pittsburgh sends Paul Skenes, the preseason favourite within the Cy Younger odds, to the hill reverse Miami’s Sandy Alcantara, the 2022-winner.

The Braves give the opening-day begin to reigning NL Cy Younger-winner Chris Sale, who toes the rubber in opposition to Padres ace Michael King.